突变研究-突变发生的基本和分子机制 SCIE

期刊简介预计审稿时间： 偏慢,4-8周

Mutation Research (MR) provides a platform for publishing all aspects of DNA mutations and epimutations, from basic evolutionary aspects to translational applications in genetic and epigenetic diagnostics and therapy. Mutations are defined as all possible alterations in DNA sequence and sequence organization, from point mutations to genome structural variation, chromosomal aberrations and aneuploidy. Epimutations are defined as alterations in the epigenome, i.e., changes in DNA methylation, histone modification and small regulatory RNAs.

MR publishes articles in the following areas:

Of special interest are basic mechanisms through which DNA damage and mutations impact development and differentiation, stem cell biology and cell fate in general, including various forms of cell death and cellular senescence.

The study of genome instability in human molecular epidemiology and in relation to complex phenotypes, such as human disease, is considered a growing area of importance.

Mechanisms of (epi)mutation induction, for example, during DNA repair, replication or recombination; novel methods of (epi)mutation detection, with a focus on ultra-high-throughput sequencing.

Landscape of somatic mutations and epimutations in cancer and aging.

Role of de novo mutations in human disease and aging; mutations in population genomics.

Interactions between mutations and epimutations.

The role of epimutations in chromatin structure and function.

Mitochondrial DNA mutations and their consequences in terms of human disease and aging.

Novel ways to generate mutations and epimutations in cell lines and animal models.

突变研究 (MR) 提供了一个平台，用于发布 DNA 突变和表观突变的各个方面，从基本的进化方面到遗传和表观遗传诊断和治疗中的转化应用。突变被定义为 DNA 序列和序列组织的所有可能改变，从点突变到基因组结构变异、染色体畸变和非整倍性。表观突变被定义为表观基因组的改变，即 DNA 甲基化、组蛋白修饰和小调节 RNA 的变化。

MR 在以下领域发表文章：

特别令人感兴趣的是 DNA 损伤和突变影响发育和分化、干细胞生物学和细胞命运的基本机制，包括各种形式的细胞死亡和细胞衰老。

人类分子流行病学中基因组不稳定性的研究以及与人类疾病等复杂表型的关系被认为是一个日益重要的领域。

（表观）突变诱导机制，例如在 DNA 修复、复制或重组过程中；检测（表观）突变的新方法，重点是超高通量测序。

癌症和衰老中的体细胞突变和表观突变概况。

新生突变在人类疾病和衰老中的作用；群体基因组学中的突变。

突变和表观突变之间的相互作用。

表观突变在染色质结构和功能中的作用。

线粒体 DNA 突变及其对人类疾病和衰老的影响。

在细胞系和动物模型中产生突变和表观突变的新方法。

《Mutation Research-fundamental And Molecular Mechanisms Of Mutagenesis》(突变研究-突变发生的基本和分子机制)编辑部通讯方式为ELSEVIER SCIENCE BV, PO BOX 211, AMSTERDAM, NETHERLANDS, 1000 AE。如果您需要协助投稿或润稿服务，您可以咨询我们的客服老师。我们专注于期刊投稿服务十年，熟悉发表政策，可为您提供一对一投稿指导，避免您在投稿时频繁碰壁，节省您的宝贵时间，有效提升发表机率，确保SCI检索（检索不了全额退款）。我们视信誉为生命，多方面确保文章安全保密，在任何情况下都不会泄露您的个人信息或稿件内容。