异生菌 SCIE

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Xenobiotica covers seven main areas, including:General Xenobiochemistry, including in vitro studies concerned with the metabolism, disposition and excretion of drugs, and other xenobiotics, as well as the structure, function and regulation of associated enzymesClinical Pharmacokinetics and Metabolism, covering the pharmacokinetics and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in manAnimal Pharmacokinetics and Metabolism, covering the pharmacokinetics, and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in animalsPharmacogenetics, defined as the identification and functional characterisation of polymorphic genes that encode xenobiotic metabolising enzymes and transporters that may result in altered enzymatic, cellular and clinical responses to xenobioticsMolecular Toxicology, concerning the mechanisms of toxicity and the study of toxicology of xenobiotics at the molecular levelXenobiotic Transporters, concerned with all aspects of the carrier proteins involved in the movement of xenobiotics into and out of cells, and their impact on pharmacokinetic behaviour in animals and manTopics in Xenobiochemistry, in the form of reviews and commentaries are primarily intended to be a critical analysis of the issue, wherein the author offers opinions on the relevance of data or of a particular experimental approach or methodology

外来生物学涵盖七个主要领域，包括：普通外来生物化学，包括与药物和其他外来生物的代谢、处置和排泄有关的体外研究，以及相关酶的结构、功能和调节；临床药代动力学和代谢，涵盖药物和其他外来生物在人体内的药代动力学和吸收、分布、代谢和排泄；动物药代动力学和代谢，涵盖药物和其他外来生物在动物内的药代动力学和吸收、分布、代谢和排泄；药物遗传学，定义为对编码外来生物代谢酶和转运蛋白的多态性基因的识别和功能表征，这些基因可能导致对外来生物的酶促、细胞和临床反应发生改变；分子毒理学，涉及外来生物的毒性机制和分子水平上的毒理学研究；外来生物转运蛋白，涉及参与药物运输的载体蛋白的所有方面。外来生物进出细胞的过程，以及它们对动物和人类药代动力学行为的影响。以评论和评注形式出现的外来生物化学主题主要旨在对问题进行批判性分析，其中作者就数据的相关性或特定的实验方法或方法论提出意见

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